Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. ChemicalBook. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. CAS #: 9004-34-6 1.6. <> Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. If breathing is difficult or if . Synergies to simplify formulation challenges and reduce operational costs. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . ( : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. Performing this action will revert the following features to their default settings: Hooray! IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Packaging: 34 x 50 kgs fiber drums. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Thus, Avicel contributes no or very few calories to the food system. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. PDF (28.38 mb) 2022 Corporate Fact Sheet. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . This Microcrystalline Cellulose . (&E. 2008-2023 ChemPoint. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. Watch Now. P}MFbN#[>r(y 9,LL!z *r_ *?~4$ &0Y# Product Name: Microcrystalline Cellulose E460 1.2. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. CAS #: 9004-34-6 . Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. % Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. /Type/Page % EMCOCEL XLM 90. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. gwf;J(e0o|1p{R~P^);ao!%{0KD7. 2021 Annual Report. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Safety Data Sheet (SDS) Viewer. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. endobj As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. : 160182. EINECS #: 232-674-9 1.7. q86@on$^X_HuH;3` Test Data Available. Avicel PH-200 microcrystalline cellulose NF, Ph. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. In extrusion-spheronisation, it is the excipient of choice. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. 5 0 obj Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. ). SDS. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Wu, K. Zuurman, H.W. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? /MediaBox [0 0 612 792] The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Manufactured by: China . The typical mean particle size is 20200 m. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . The data shown below apply only to Avicel PH 101. Cellulose microcrystalline. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. (1962). AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. It . When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. : 160182 Date Approved: 05/25/2010 Revision No. Go to Investor Relations. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . Your file is uploaded and ready to be published. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). Unique functionality for a broad range of pharmaceutical applications. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. FMC, JRS and Mingtai were estimated to hold for . X\o^ q9;v80 Meet our leadership team. Microcrystalline Cellulose NF. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. << Validity Area. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. Document(s): certificate data msds. l~5C Hi, let us know if you have any questions as you visit our website. These grades have particle sizes ranging from <30 to approximately 200. Have an order or account question? Request media, explore upcoming events and read our latest updates. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against CAS 9004-34-6, pH 5 - 7.5. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. . . The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. Revision No. CAS No. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Chemical Formula: (C6H10O5)n 1.4. Some substance identifiers may have been claimed confidential, or may . For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Regulatory Information Find answers in our support articles. Report Category. We are artists at heart and creators by nature. No. endobj PharmaCentral 2021 . <> MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? };khd5x=fr 0.25 - 0.37. cas:9032-51-3 msds CELLULOSE PAB. 4 0 obj iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM endobj Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine endobj Avicel PC 611 (FMC Biopolymer) . MATERIAL SAFETY DATA SHEET. Learn about FMC's industry leading goal of net-zero emissions by 2035. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. 8 0 obj CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Superior Performance: Provides excellent water uptake and rapid swelling . It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Manufacturer: FMC BioPolymer. . Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. >> The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Combines good flow and high compactibility. 3 0 obj % METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Microcrystalline Cellulose Side Effects. Medium size standard MCC grade, suited for the majority of directly compressible actives. Earth Supplied Products LLC. Safety Data Sheet for Cellulose microcrystalline 102331. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Van Veen, G.K. Bolhuis, Y.S. Microcrystalline Cellulose / Avicel PH-102. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Catalog Number 102331. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Molecular weight: Not Applicable 1.5. Delivering efficient and robust formulations. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. POLYOX resins are nonionic polyethylene oxide solubility polymers. Microcrystalline Cellulose (MCC) Manufacturing Industry. Microcrystalline Cellulose E460 MSDS 1. MATERIAL SAFETY DATA SHEET. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Browse Avicel PH-101 and related products at MilliporeSigma. It is also inert and biocompatible. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Alginates also function as actives in some anti-reflux products. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Aqueous suspensions of microcrystalline cellulose have . stream The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. G2W4de=u183KGH{ vQ#4:1\wc gac74 [#B6`Wnw7 These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. . ( It is, however, a good source of fibre. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . No. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. Synonyms: Cellulose, Cellulose powder, Cotton linters. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. common form is used in vitamin supplements or tablets. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& Material safety data sheet - FMC Corporation. << FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. stream The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. The short-term limit for total inhalable dust is 20 mg/m3. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. However, it yields non-digestible fibre. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. 1.3. MSDS Ref. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Terms and Conditions Compliance Solutions Industries About 3E News & Events . Trademarks: Avicel PH-102. The cellulose molecule is formed through repeated condensation of cellobiose units. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . 1.3. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. stream Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical.
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